التداخل بين أتينولول ودرونيدارون

Amiodarone is an antiarrhythmic agent with negative chronotropic properties that may be additive to those seen with beta-blockers.

Disopyramide is a Type I antiarrhythmic drug with potent negative inotropic and chronotropic effects.

Give a low dose of beta-blockers initially, and increase only after ECG verification of good tolerability [see Drug Interactions (7.3) , Clinical Pharmacology (12.3) ] .

Beta-Blockers and Other CYP2D6 Substrates Dronedarone increased the exposure of propranolol and metoprolol.

Give low doses of beta-blockers initially, and increase only after ECG verification of good tolerability.

Other CYP2D6 substrates, including other beta-blockers, tricyclic antidepressants, and selective serotonin reuptake inhibitors (SSRIs) may have increased exposure upon coadministration with dronedarone [see Drug Interactions (7.1) , Clinical Pharmacology (12.3) ] .

• Beta-blockers: May provoke excessive bradycardia.