التداخل بين أتورفاستاتين ونورجيستيمات وإيثينيل إستراديول

• Oral Contraceptives: May increase plasma levels of norethindrone and ethinyl estradiol; consider this effect when selecting an oral contraceptive ( 7.3 ).

Table 4: LIPITOR Effects on Other Drugs Oral Contraceptives Clinical Impact: Co-administration of LIPITOR and an oral contraceptive increased plasma concentrations of norethindrone and ethinyl estradiol [see Clinical Pharmacology (12.3) ].

Intervention: Consider this when selecting an oral contraceptive for patients taking LIPITOR.

Substances increasing the plasma concentrations of COCs Co-administration of atorvastatin or rosuvastatin and certain COCs containing ethinyl estradiol (EE) increase AUC values for EE by approximately 20-25%.