التداخل بين بيسوبرولول وهيدروكلوروثيازيد وبوتالبيتال وأسبرين وكافيين

Alcohol, barbiturates, or narcotics - potentiation of orthostatic hypotension may occur.

Nonsteroidal anti-inflammatory drugs - In some patients, the administration of a nonsteroidal anti-inflammatory agent can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium sparing, and thiazide diuretics.

Therefore, when bisoprolol fumarate and hydrochlorothiazide tablets and nonsteroidal anti-inflammatory agents are used concomitantly, the patient should be observed closely to determine if the desired effect of the diuretic is obtained.