التداخل بين بيسوبرولول وهيدروكلوروثيازيد وليثيوم

• Diuretics, NSAID, renin-angiotensin system antagonists, or metronidazole may increase lithium serum concentrations.

Drugs Having Clinically Important Interactions with Lithium Table 4: Clinically Important Drug Interactions with Lithium Diuretics Clinical Impact: Diuretic-induced sodium loss may reduce lithium clearance and increase serum lithium concentrations .

Diuretic agents reduce the renal clearance of lithium and add a high risk of lithium toxicity.

Lithium - generally should not be given with diuretics.

Refer to the package insert for lithium preparations before use of such preparations with bisoprolol fumarate and hydrochlorothiazide tablets.