التداخل بين بوسنتان ونينتيدانيب

Coadministration with oral doses of a P-gp and CYP3A4 inducer, rifampicin, decreased exposure to nintedanib by 50%.

Concomitant use of P-gp and CYP3A4 inducers (e.g., carbamazepine, phenytoin, and St.

Bosentan Coadministration of nintedanib with bosentan did not alter the pharmacokinetics of nintedanib [see Clinical Pharmacology (12.3) ] .