التداخل بين بوسنتان وفيراباميل

Co-administration of such combinations of a CYP2C9 inhibitor plus a strong or moderate CYP3A inhibitor with TRACLEER is not recommended.

Concomitant administration of both a CYP2C9 inhibitor (such as fluconazole or amiodarone) and a strong CYP3A inhibitor (e.g., ketoconazole, itraconazole) or a moderate CYP3A inhibitor (e.g., amprenavir, erythromycin, fluconazole, diltiazem) with TRACLEER will likely lead to large increases in plasma concentrations of bosentan.

CYP3A4 inducers decrease verapamil levels ( 7.1 )

Inducers of CYP3A4 (e.g., rifampin) have caused a lowering of plasma levels of verapamil.