التداخل بين بريمونيدين وديسيبرامين

Use with CNS depressants may result in an additive or potentiating effect.

CNS Depressants Although specific drug interaction studies have not been conducted with brimonidine tartrate ophthalmic solution 0.1% and 0.15%, the possibility of an additive or potentiating effect with CNS depressants (alcohol, barbiturates, opiates, sedatives, or anesthetics) should be considered.

Caution is advised in patients taking tricyclic antidepressants which can affect the metabolism and uptake of circulating amines.

Tricyclic antidepressants may potentially blunt the hypotensive effect of systemic clonidine.

Tricyclic Antidepressants Tricyclic antidepressants have been reported to blunt the hypotensive effect of systemic clonidine.