التداخل بين بريمونيدين وتيمولول وفلوكسيتين

CYP2D6 inhibitors may potentiate systemic beta-blockade.

CYP2D6 Inhibitors Potentiated systemic beta-blockade (e.g., decreased heart rate, depression) has been reported during combined treatment with CYP2D6 inhibitors (e.g., quinidine, SSRIs) and timolol.

Caution, however, is advised in patients taking tricyclic antidepressants which can affect the metabolism and uptake of circulating amines.

Tricyclic antidepressants may potentially blunt the hypotensive effect of systemic clonidine.

Tricyclic Antidepressants Tricyclic antidepressants have been reported to blunt the hypotensive effect of systemic clonidine.