التداخل بين برومفينيرامين وسودوإيفيدرين وديكستروميثورفان وراساجيلين

Rasagiline is contraindicated for use with dextromethorphan because of risk of episode of psychosis or bizarre behavior.

Concomitant use of meperidine, tramadol, methadone, propoxyphene dextromethorphan, St.

Therefore, in view of rasagiline’s MAO inhibitory activity, dextromethorphan is contraindicated for use with rasagiline [see Contraindications ( 4 )] .

Dextromethorphan: Risk of psychosis or bizarre behavior ( 4 , 7.2 )

Hypertensive crisis has been reported in patients taking the recommended dose of rasagiline and sympathomimetic medications.

Do not use dextromethorphan in patients receiving monoamine oxidase (MAOI) inhibitors ( see PRECAUTIONS – Drug Interactions ).

Drug Interactions Monoamine oxidase (MAO) inhibitors Hyperpyrexia, hypotension, and death have been reported coincident with the coadministration of MAO inhibitors and products containing dextromethorphan.

Concomitant administration of Brompheniramine Maleate, Pseudoephedrine Hydrochloride and Dextromethorphan Hydrobromide Oral Syrup and MAO inhibitors should be avoided ( see CONTRAINDICATIONS ).

In addition, MAO inhibitors prolong and intensify the anticholinergic (drying) effects of antihistamines and may enhance the effect of pseudoephedrine.