التداخل بين بوتالبيتال وباراسيتامول وكافيين وبروتريبتيلين

Butalbital, acetaminophen and caffeine may enhance the effects of: other narcotic analgesics, alcohol, general anesthetics, tranquilizers such as chlordiazepoxide, sedative-hypnotics, or other CNS depressants, causing increased CNS depression.

Drug Interactions When protriptyline is given with anticholinergic agents or sympathomimetic drugs, including epinephrine combined with local anesthetics, close supervision and careful adjustment of dosages are required.

Protriptyline may enhance the response to alcohol and the effects of barbiturates and other CNS depressants.