التداخل بين بوتالبيتال وأسبرين وكافيين وفلودروكورتيزون

Aspirin — increased ulcerogenic effect; decreased pharmacologic effect of aspirin.

Rarely salicylate toxicity may occur in patients who discontinue steroids after concurrent high-dose aspirin therapy.

Monitor salicylate levels or the therapeutic effect for which aspirin is given; adjust salicylate dosage accordingly if effect is altered (see PRECAUTIONS, General ).

Barbiturates, phenytoin, or rifampin —increased metabolic clearance of fludrocortisone acetate because of the induction of hepatic enzymes.

In patients receiving concomitant corticosteroids and chronic use of aspirin, withdrawal of corticosteroids may result in salicylism because corticosteroids enhance renal clearance of salicylates and their withdrawal is followed by return to normal rates of renal clearance.