التداخل بين بوتالبيتال وأسبرين وكافيين وكودايين وفوروسيميد

• Salicylates : Risk of salicylate toxicity ( 7.1 )

Salicylates May experience salicylate toxicity at lower doses because of competitive renal excretory sites.

Monitor for symptoms of salicylate toxicity.

Indomethacin Coadministration of indomethacin may reduce the natriuretic and antihypertensive effects of furosemide in some patients by inhibiting prostaglandin synthesis.

Diuretics Clinical Impact: Opioids can reduce the efficacy of diuretics by inducing the release of antidiuretic hormone.

Intervention: Evaluate patients for signs of diminished diuresis and/or effects on blood pressure and increase the dosage of the diuretic as needed.

The effectiveness of diuretics in patients with underlying renal or cardiovascular disease may be diminished by the concomitant administration of aspirin due to inhibition of renal prostaglandins, leading to decreased renal blood flow and salt and fluid retention.