التداخل بين بوتورفانول وميثيل نالتريكسون

Management of respiratory depression may include close observation, supportive measures, and use of opioid overdose reversal agents (e.g., naloxone, nalmefene), depending on the patient's clinical status [see OVERDOSAGE ].

If concomitant use is warranted, consider ‎prescribing naloxone for the emergency treatment of opioid overdose.

In patients who are not opioid dependent, naloxone has also been reported to be effective.

• Other Opioid Antagonists : Potential for additive effect and increased risk of opioid withdrawal; avoid concomitant use.

Other Opioid Antagonists Avoid concomitant use of RELISTOR with other opioid antagonists because of the potential for additive effects of opioid receptor antagonism and increased risk of opioid withdrawal.

• Opioid Withdrawal : Consider the overall risk benefit in patients with disruptions to the blood-brain barrier.

Monitor closely for symptoms of opioid withdrawal.

Patients having disruptions to the blood-brain barrier may be at increased risk for opioid withdrawal and/or reduced analgesia.