التداخل بين بوتورفانول ونالوكسون

In neonates, opioid withdrawal may be life-threatening if not recognized and properly treated.

In neonates, opioid withdrawal may be life-threatening if not recognized and properly treated and may include the following signs and symptoms: convulsions, excessive crying, and hyperactive reflexes.

There may be clinical settings, particularly the postpartum period in neonates with known or suspected exposure to maternal opioid use, where it is preferable to avoid the abrupt precipitation of opioid withdrawal symptoms.

WARNINGS AND PRECAUTIONS Risk of Recurrent Respiratory and CNS Depression : Due to the duration of action of naloxone relative to the opioid, respiratory and CNS depression may recur after the first dose of naloxone.

Monitor for the development of opioid withdrawal.

Management of respiratory depression may include close observation, supportive measures, and use of opioid overdose reversal agents (e.g., naloxone, nalmefene), depending on the patient's clinical status [see OVERDOSAGE ].

If concomitant use is warranted, consider ‎prescribing naloxone for the emergency treatment of opioid overdose.

In patients who are not opioid dependent, naloxone has also been reported to be effective.