التداخل بين كانديسارتان وهيدروكلوروثيازيد وفينترمين وتوبيرامات

Concomitant administration of hydrochlorothiazide alone with topiramate alone has been shown to increase the C max and AUC of topiramate by 27% and 29%, respectively.

In addition, when phentermine and topiramate extended-release capsules are used in conjunction with nonpotassium sparing diuretics this may further potentiate potassium-wasting.

…phentermine and topiramate extended-release capsules dosage reduction or discontinuation if cognitive dysfunction persists [see Warnings and Precautions (5.5) ] Non-Potassium Sparing Diuretics Clinical Impact Concurrent use of phentermine and topiramate extended-release capsules with non-potassium sparing diuretics may potentiate the potassium-wasting action of…

Intervention When phentermine and topiramate extended-release capsules are used concomitantly with non-potassium-sparing diuretics, measure potassium before and during phentermine and topiramate extended-release capsules treatment [see Warnings and Precautions (5.12) and Clinical Pharmacology (12.3) ] .

Non-potassium Sparing Diuretics : May potentiate hypokalemia.