التداخل بين كانابيديول (بوصفة طبية) وكلوبيدوغريل

CYP2C19 inhibitors: Avoid concomitant use of omeprazole or esomeprazole.

The metabolism of clopidogrel can also be impaired by drugs that inhibit CYP2C19, such as omeprazole or esomeprazole.

CYP2C19 Inhibitors Clopidogrel is metabolized to its active metabolite in part by CYP2C19.

However, at high concentrations in vitro , clopidogrel inhibits CYP2C9.

Repaglinide (CYP2C8 Substrates) The acyl-β-glucuronide metabolite of clopidogrel is a strong inhibitor of CYP2C8.

For CYP2C19 substrates (e.g., clopidogrel) where efficacy is mainly due to their active metabolite(s), concomitant use of EPIDIOLEX may decrease plasma concentration of the active metabolite(s) and may therefore decrease efficacy.