التداخل بين كانابيديول (بوصفة طبية) وإيفافيرينز

• Strong inducer of CYP3A4 or CYP2C19: Consider dose increase of EPIDIOLEX.

Patients who are receiving concomitant anticonvulsant medications primarily metabolized by the liver, such as phenytoin and phenobarbital, may require periodic monitoring of plasma levels [see Drug Interactions ( 7.1 ) ] .

Anticonvulsants:Carbamazepine PhenytoinPhenobarbital ↓ carbamazepine * ↓ efavirenz * ↓ anticonvulsant ↓ efavirenz There are insufficient data to make a dose recommendation for efavirenz.

Potential for reduction in anticonvulsant and/or efavirenz plasma levels; periodic monitoring of anticonvulsant plasma levels should be conducted.

Alternative anticonvulsant treatment should be used.

Cannabinoid Test Interaction Efavirenz does not bind to cannabinoid receptors.