التداخل بين كانابيديول (بوصفة طبية) وإيفافيرينز ولاميفودين وتينوفوفير

• Strong inducer of CYP3A4 or CYP2C19: Consider dose increase of EPIDIOLEX.

Patients who are receiving concomitant anticonvulsant medications primarily metabolized by the liver, such as phenytoin and phenobarbital, may require periodic monitoring of plasma levels [see Drug Interactions (7.5) ] .

Phenytoin Phenobarbital ↓ anticonvulsant ↓ EFV Monitor anticonvulsant plasma levels periodically because of potential for reduction in anticonvulsant and/or EFV plasma levels.

Cannabinoid Test Interaction EFV does not bind to cannabinoid receptors.

False-positive urine cannabinoid test results have been reported with some screening assays in uninfected and HIV-infected subjects receiving EFV.

Confirmation of positive screening tests for cannabinoids by a more specific method is recommended.