التداخل بين كانابيديول (بوصفة طبية) ولاكوساميد

Anyone considering prescribing VIMPAT or any other AED must balance this risk with the risk of untreated illness.

Strong CYP3A4 or CYP2C9 Inhibitors Patients with renal or hepatic impairment who are taking strong inhibitors of CYP3A4 and CYP2C9 may have a significant increase in exposure to VIMPAT.

Other CNS depressants, including alcohol, could potentiate the somnolence and sedation effect of EPIDIOLEX.

Effect of EPIDIOLEX on Other Drugs Antiepileptic Drugs Clobazam Concomitant use of EPIDIOLEX with clobazam increases plasma concentrations of N‑desmethylclobazam, the active metabolite of clobazam [see Clinical Pharmacology ( 12.3 )], which may increase the risk of clobazam-related adverse reactions [see Adverse Reactions ( 6.1 ) and Warnings and Precautions…