التداخل بين كاربامازيبين وإيزونيازيد

Concomitant use of monoamine oxidase inhibitors (MAOIs).

Before beginning treatment with EQUETRO, MAOIs should be discontinued for a minimum of 14 days.

Concomitant use with monoamine oxidase inhibitors (MAOIs) or use within 14 days of discontinuing an MAOI ( 4 )

Pharmacodynamic Drug Interactions M onoamine O xidase I nhibitors Concomitant treatment with EQUETRO is contraindicated during use of an MAOI or within 14 days after discontinuing an MAOI.

Isoniazid Concomitant use of carbamazepine and isoniazid has been reported to increase isoniazid-induced hepatotoxicity.

To avoid phenytoin intoxication, appropriate adjustment of the anticonvulsant should be made 5,6 .

Carbamazepine Isoniazid is known to slow the metabolism of carbamazepine and increase its serum levels.

Carbamazepine levels should be determined prior to concurrent administration with isoniazid, signs and symptoms of carbamazepine toxicity should be monitored closely, and appropriate dosage adjustment of the anticonvulsant should be made 3 .