التداخل بين كاربامازيبين وبريميدون

CNS Depressants The concomitant use of EQUETRO and other CNS depressants can increase the risk of respiratory depression, profound sedation, hypotension, and syncope.

EQUETRO increases the plasma levels of the following drugs by inhibition of their metabolism : Clomipramine, P henytoin, and P rimidone EQUETRO can increase the concentrations of clomipramine, phenytoin, and primidone.

Limited evidence suggests that HLA-B*1502 may be a risk factor for the development of SJS/TEN in patients of Chinese ancestry taking other anti-epileptic drugs associated with SJS/TEN, including phenytoin.

Consider reducing the dose of CNS depressants or EQUETRO when using these drugs concomitantly.

Hypersensitivity Hypersensitivity reactions to carbamazepine have been reported in patients who previously experienced this reaction to anticonvulsants including phenytoin, primidone, and phenobarbital.

Neonatal hemorrhage, with a coagulation defect resembling vitamin K deficiency, has been described in newborns whose mothers were taking primidone and other anticonvulsants.