التداخل بين كاربيدوبا وليفودوبا وإنتاكابون وفينيتوين

• Dopamine D2 receptor antagonists, isoniazid, phenytoin, papaverine and iron salts: may reduce efficacy of Carbidopa, levodopa and entacapone tablets ( 7.5 , 7.6 , 7.7 , 7.8 , 7.9 ) • Drugs that interfere with biliary excretion, glucuronidation and intestinal beta-glucuronidase: dose adjustment of Carbidopa, levodopa and entacapone tablets may be required (…

Carbidopa, levodopa and entacapone tablets dosage should be increased as clinically needed in patients receiving phenytoin.

Phenytoin The beneficial effects of levodopa in Parkinson’s disease have been reported to be reversed by phenytoin.

Patients taking phenytoin with carbidopa/levodopa should be carefully observed for loss of therapeutic response.