التداخل بين كاربيدوبا وليفودوبا وإنتاكابون ووارفارين

• Drugs metabolized by CYP2C9 (e.g., coumadin): dose adjustment of Carbidopa, levodopa and entacapone tablets may be required; monitor INR when initiating Carbidopa, levodopa and entacapone tablets in patients on coumadin ( 7.11 )

Drugs Metabolized via CYP2C9 (e.g.,coumadin) The dosage of Carbidopa, levodopa and entacapone tablets should be adjusted as clinically needed in patients using other drugs metabolized via CYP2C9.

An interaction study in healthy volunteers, entacapone increased the AUC of R-warfarin on average by 18%, and the INR values on average by 13%.

Cases of increased INR in patients concomitantly using warfarin have been reported during the post-approval use of entacapone.

Thus, monitoring of INR is recommended when Carbidopa, levodopa and entacapone tablets treatment is initiated for patients receiving warfarin.