التداخل بين كارفيديلول وسيميتيدين

Cimetidine increased AUC by about 30% but caused no change in C max [see Clinical Pharmacology (12.5) ] .

CYP2D6 Inhibitors and Poor Metabolizers Interactions of carvedilol with potent inhibitors of CYP2D6 isoenzyme (such as quinidine, fluoxetine, paroxetine, and propafenone) have not been studied, but these drugs would be expected to increase blood levels of the R(+) enantiomer of carvedilol [see Clinical Pharmacology (12.3) ].