التداخل بين سينوبامات ولاموتريجين

Patients with History of Allergy or Rash to Other Antiepileptic Drugs The risk of rash may be increased in patients with a history of allergy or rash to other AEDs.

Lamotrigine, Carbamazepine: Increase dosage as needed when used concomitantly with XCOPRI.

Table 5: Pharmacokinetic Drug Interactions Drug or Substrate Type Effect of XCOPRI on Drug or Substrate Clinical Recommendation Antiepileptic Drugs lamotrigine ↓ plasma concentrations Because of a potential for reduced efficacy of these drugs, increase the dosage of lamotrigine or carbamazepine, as needed, when used concomitantly with XCOPRI. carbamazepine ↓…

Anyone considering prescribing XCOPRI or any other AED must balance this risk with the risk of untreated illness.