التداخل بين سينوبامات وتوبيرامات

Because of the potential of topiramate to cause CNS depression, as well as other cognitive and/or neuropsychiatric adverse reactions, topiramate extended-release capsules should be used with extreme caution if used in combination with alcohol and other CNS depressants.

Concomitant use with other CNS depressants or alcohol may have additive effects.

Anyone considering prescribing XCOPRI or any other AED must balance this risk with the risk of untreated illness.

Patients should be carefully observed for signs of central nervous system (CNS) depression, such as somnolence and sedation, when XCOPRI is used with other drugs with sedative properties because of potential additive effects.