التداخل بين كلورديازيبوكسيد وبوساكونازول

Concomitant Use with Midazolam : Noxafil can prolong hypnotic/sedative effects.

Monitor patients and benzodiazepine receptor antagonists should be available.

Increased plasma midazolam concentrations could potentiate and prolong hypnotic and sedative effects.

Patients must be monitored closely for adverse effects associated with high plasma concentrations of midazolam and benzodiazepine receptor antagonists must be available to reverse these effects [see Drug Interactions (7.2) and Clinical Pharmacology (12.3) ] .

Benzodiazepines that are CYP3A4 Substrates Mechanism and Clinical Effect(s) Concomitant use of posaconazole with midazolam increased midazolam plasma concentrations which could potentiate and prolong hypnotic and sedative effects [see Clinical Pharmacology (12.3) ] .