التداخل بين كلوربرومازين وفينترمين وتوبيرامات

Therefore, dosage of anticonvulsants, including barbiturates, should not be reduced if chlorpromazine is started.

Chlorpromazine may lower the convulsive threshold; dosage adjustments of anticonvulsants may be necessary.

Note: Chlorpromazine does not intensify the anticonvulsant action of barbiturates.

Potentiation of anticonvulsant effects does not occur.

The concomitant use of alcohol or central nervous system (CNS) depressant drugs with phentermine and topiramate extended-release capsules may potentiate CNS depression or other centrally mediated effects of these agents, such as dizziness, cognitive adverse reactions, drowsiness, light-headedness, impaired coordination, and somnolence.

CNS Depressants Including Alcohol Clinical Impact The concomitant use of alcohol or CNS depressant drugs (e.g., barbiturates, benzodiazepines, and sleep medications) with phentermine or topiramate may potentiate CNS depression such as dizziness or cognitive adverse reactions, or other centrally mediated effects of these agents.

CNS Depressants Including Alcohol : May potentiate CNS depressant effects.