التداخل بين كلوربرومازين وزونيساميد

Caution should be used when ZONISADE is prescribed with other drugs that predispose patients to heat-related disorders; these drugs include, but are not limited to, carbonic anhydrase inhibitors and drugs with anticholinergic activity.

Patients should be carefully observed for signs of central nervous system (CNS) depression, such as somnolence and sedation, when ZONISADE is used with other drugs with sedative properties because of potential additive effects.

• ZONISADE should be used with caution if used in combination with alcohol or other CNS depressants ( 7.1 ).

CNS Depressants Concomitant use of ZONISADE with other CNS depressants, including alcohol, may increase the risk of CNS depression, as well as other cognitive and/or neuropsychiatric adverse events [see Warnings and Precautions ( 5.11 )] .

Therefore, dosage of anticonvulsants, including barbiturates, should not be reduced if chlorpromazine is started.

Chlorpromazine may lower the convulsive threshold; dosage adjustments of anticonvulsants may be necessary.

Note: Chlorpromazine does not intensify the anticonvulsant action of barbiturates.

Potentiation of anticonvulsant effects does not occur.