التداخل بين كلورثاليدون وليثيوم

Lithium renal clearance is reduced by chlorthalidone, increasing the risk of lithium toxicity.

Monitor serum lithium levels during concomitant use.

• Lithium: Lithium renal clearance is reduced by chlorthalidone, increasing the risk of lithium toxicity (7).

• Diuretics, NSAID, renin-angiotensin system antagonists, or metronidazole may increase lithium serum concentrations.

Drugs Having Clinically Important Interactions with Lithium Table 4: Clinically Important Drug Interactions with Lithium Diuretics Clinical Impact: Diuretic-induced sodium loss may reduce lithium clearance and increase serum lithium concentrations .