التداخل بين كلورزوكسازون وبروتريبتيلين

Chlorzoxazone use should also be discontinued if a patient develops abnormal liver enzymes (e.g., AST, ALT, alkaline phosphatase and bilirubin.) The concomitant use of alcohol or other central nervous system depressants may have an additive effect.

Protriptyline may enhance the response to alcohol and the effects of barbiturates and other CNS depressants.