التداخل بين سيكليسونيد وإيفيروليموس

In a drug interaction study, co-administration of orally inhaled ciclesonide and oral ketoconazole, a potent inhibitor of cytochrome P450 3A4, increased the exposure (AUC) of des-ciclesonide by approximately 3.6-fold at steady state, while levels of ciclesonide remained unchanged.

Corticosteroids may be indicated until clinical symptoms resolve.

Administer prophylaxis for PJP when concomitant use of corticosteroids or other immunosuppressive agents are required.