التداخل بين سيميتيدين وغابابنتين

Cimetidine In the presence of cimetidine at 300 mg four times a day (N=12), the mean apparent oral clearance of gabapentin fell by 14% and creatinine clearance fell by 10%.

Thus, cimetidine appeared to alter the renal excretion of both gabapentin and creatinine, an endogenous marker of renal function.

The effect of gabapentin on cimetidine was not evaluated.

This decrease in excretion of gabapentin by cimetidine is not expected to be of clinical importance.