التداخل بين كلاريثرومايسين وإيفيروليموس

Strong CYP3A inhibitor and P-gp inhibitor : Avoid coadministration.

Effect of Other Drugs on AFINITOR/AFINITOR DISPERZ Strong or Moderate CYP3A Inhibitor and P-gp Inhibitor Avoid the coadministration of a strong CYP3A inhibitor and P-gp inhibitor [see Dosage and Administration (2.11), Clinical Pharmacology (12.3)] .

Moderate CYP3A inhibitor and P-gp inhibitor : Reduce the dosage as recommended.

Clarithromycin and other macrolides are known to inhibit CYP3A and Pgp.

Clarithromycin and other macrolides are known to inhibit CYP3A.

…Repaglinide, Rosiglitazone: [See Warnings and Precautions ( 5.4 ) and Adverse Reactions ( 6.2 )] Insulin Insulin: [See Warnings and Precautions ( 5.4 ) and Adverse Reactions ( 6.2 )] Immunosuppressants: Cyclosporine Use With Caution Cyclosporine: There have been spontaneous or published reports of CYP3A based interactions of clarithromycin with cyclosporine.