التداخل بين كلاريثرومايسين وفيداكسوميسين

Concentrations of fidaxomicin and OP-1118 may also be decreased at the site of action (i.e., gastrointestinal tract) via P-gp inhibition; however, concomitant P-gp inhibitor use had no attributable effect on safety or treatment outcome of fidaxomicin-treated adult patients in controlled clinical trials.

Some patients with hypersensitivity reactions to DIFICID also reported a history of allergy to other macrolides.

Based on these results, fidaxomicin may be co-administered with P-gp inhibitors and no dose adjustment is recommended.

Clarithromycin and other macrolides are known to inhibit CYP3A and Pgp.

Clarithromycin and other macrolides are known to inhibit CYP3A.