التداخل بين سيكلوسبورين ومودافينيل

Effects of PROVIGIL on CYP3A4/5 Substrates The clearance of drugs that are substrates for CYP3A4/5 (e.g., steroidal contraceptives, cyclosporine, midazolam, and triazolam) may be increased by PROVIGIL via induction of metabolic enzymes, which results in lower systemic exposure.

Blood levels of cyclosporine may be reduced when used with PROVIGIL.

Monitoring of circulating cyclosporine concentrations and appropriate dosage adjustment for cyclosporine should be considered when used concomitantly with PROVIGIL.

Cyclosporine: Blood concentrations of cyclosporine may be reduced.