التداخل بين سيكلوسبورين وتيربينافين

Terbinafine increases the clearance of cyclosporine by 15%.

Drug interactions have also been noted with cimetidine, fluconazole, cyclosporine, rifampin, and caffeine.

In vitro studies with human liver microsomes showed that terbinafine does not inhibit the metabolism of tolbutamide, ethinylestradiol, ethoxycoumarin, cyclosporine, cisapride and fluvastatin.

Terbinafine clearance is unaffected by cyclosporine.

John’s Wort rifampin oxcarbazepine octreotide phenobarbital orlistat phenytoin sulfinpyrazone terbinafine ticlopidine Bosentan Coadministration of bosentan (250 to 1000 mg every 12 hours based on tolerability) and cyclosporine (300 mg every 12 hours for 2 days then dosing to achieve a C min of 200 to 250 ng/mL) for 7 days in healthy subjects resulted in decreases…