التداخل بين دارونافير وكوبيسيستات وبروبينيسيد وكولشيسين

Alpha 1-adrenoreceptor antagonist: alfuzosin Anticonvulsants: carbamazepine, phenobarbital, phenytoin Anti-gout: colchicine, in patients with renal and/or hepatic impairment Antimycobacterial: rifampin Antipsychotics: lurasidone, pimozide Cardiac Disorders: dronedarone, ivabradine, ranolazine Ergot derivatives, e.g. dihydroergotamine, ergotamine, methylergonovine…

Anti-gout: colchicine ↑ colchicine Co-administration is contraindicated in patients with renal and/or hepatic impairment due to potential for serious and/or life-threatening reactions.

For patients without renal or hepatic impairment: Treatment of gout flares – co-administration of colchicine : 0.6 mg (1 tablet) × 1 dose, followed by 0.3 mg (half tablet) 1 hour later.

Prophylaxis of gout flares – co-administration of colchicine : If the original regimen was 0.6 mg twice a day, the regimen should be adjusted to 0.3 mg once a day.

Treatment of familial Mediterranean fever – co-administration of colchicine : Maximum daily dose of 0.6 mg (may be given as 0.3 mg twice a day).