التداخل بين دارونافير ودورزولاميد وتيمولول

CYP2D6 inhibitors may potentiate systemic beta-blockade.

CYP2D6 Inhibitors Potentiated systemic beta-blockade (e.g., decreased heart rate, depression) has been reported during combined treatment with CYP2D6 inhibitors (e.g., quinidine, SSRIs) and timolol.

Use with caution in patients with a known sulfonamide allergy.

PREZISTA should be used with caution in patients with a known sulfonamide allergy.

…initial dosing and titration of quetiapine. e.g. perphenazine, risperidone, thioridazine ↑ antipsychotics A decrease in the dose of antipsychotics that are metabolized by CYP3A or CYP2D6 may be needed when co-administered with PREZISTA/ritonavir. β-Blockers : e.g. carvedilol, metoprolol, timolol ↑ beta-blockers Clinical monitoring of patients is recommended.

A dose decrease may be needed for these drugs when co-administered with PREZISTA/ritonavir and a lower dose of the beta blocker should be considered.

Sulfa Allergy Darunavir contains a sulfonamide moiety.