التداخل بين دارونافير وفوسامبرينافير

Co-administration of darunavir and ritonavir and other drugs that inhibit CYP3A, or P-gp may decrease the clearance of darunavir and ritonavir and may result in increased plasma concentrations of darunavir and ritonavir (see Table 10 ).

Other HIV protease inhibitors, except atazanavir [see Drug Interactions (7.4) ] As co-administration with PREZISTA/ritonavir has not been studied, co-administration is not recommended.

Because ritonavir is a CYP2D6 inhibitor, clinically significant interactions with drugs metabolized by CYP2D6 are possible when coadministered with fosamprenavir calcium plus ritonavir.