التداخل بين ديجوكسين ودوفيتيليد

NA – Not available/reported 7.3 Pharmacodynamic Drug Interactions Antiarrhythmics Dofetilide Concomitant administration with digoxin was associated with a higher rate of torsades de pointes .

In patients, the concomitant administration of digoxin with dofetilide was associated with a higher occurrence of Torsade de Pointes.

It is not clear whether this represents an interaction with dofetilide or the presence of more severe structural heart disease in patients on digoxin; structural heart disease is a known risk factor for arrhythmia.

No increase in mortality was observed in patients taking digoxin as concomitant medication.

Concomitant medications were grouped as ACE inhibitors, oral anticoagulants, calcium channel blockers, beta blockers, cardiac glycosides, inducers of CYP3A4, substrates and inhibitors of CYP3A4, substrates and inhibitors of P-glycoprotein, nitrates, sulphonylureas, loop diuretics, potassium sparing diuretics, thiazide diuretics, substrates and inhibitors of tubular…

Other Drug Interaction Information Digoxin: Studies in healthy volunteers have shown that dofetilide does not affect the pharmacokinetics of digoxin.