التداخل بين ديجوكسين ونابروكسين وإيزوميبرازول

…to 49% NA Ticagrelor 31% 28% Tolvaptan 30% 20% Trimethoprim 22 to 28% NA Digoxin Concentrations Increased, but Magnitude is Unclear Alprazolam, Azithromycin, Cyclosporine, Diclofenac, Diphenoxylate, Epoprostenol, Esomeprazole, Ibuprofen, Ketoconazole, Lansoprazole, Metformin, Omeprazole Measure serum digoxin concentrations before initiating concomitant drugs.

For patients expected to be on prolonged treatment or who take PPIs with medications such as digoxin or drugs that may cause hypomagnesemia (e.g., diuretics), health care professionals may consider monitoring magnesium levels prior to initiation of PPI treatment and periodically [see Adverse Reactions (6.2) ].

Digoxin Clinical Impact : Naproxen • The concomitant use of naproxen with digoxin has been reported to increase the serum concentration and prolong the half-life of digoxin.

Esomeprazol e Magnesium • Potential for increased exposure of digoxin [see Clinical Pharmacology (12.3) ].

Intervention : Monitor digoxin concentrations during concomitant use of naproxen and esomeprazole magnesium delayed-release tablets.

Dose adjustment of digoxin may be needed to maintain therapeutic drug concentrations.