التداخل بين ديجوكسين ورانولازين

Drugs transported by P-gp (e.g., digoxin), or drugs metabolized by CYP2D6 (e.g., tricyclic antidepressants) may need reduced doses when used with ASPRUZYO Sprinkle.

Drugs Transported by P-gp Concomitant use of ASPRUZYO Sprinkle and digoxin results in increased exposure to digoxin.

The dose of digoxin may have to be adjusted [see Clinical Pharmacology (12.3)].