التداخل بين ديجوكسين وفيراباميل

Beta-adrenergic Blockers and Calcium Channel Blockers Additive effects on AV node conduction can result in complete heart block.

Digoxin levels can increase by 50 to 75%; reduce digoxin dose ( 7.5 )

Monitor digoxin level periodically during therapy.

Verapamil may reduce total body clearance and extrarenal clearance of digoxin by 27% and 29%, respectively.

If digoxin toxicity is suspected, suspend or discontinue digoxin therapy.

In previous clinical trials with other verapamil formulations related to the control of ventricular response in patients taking digoxin who had atrial fibrillation or atrial flutter, ventricular rates below 50/min at rest occurred in 15% of patients, and asymptomatic hypotension occurred in 5% of patients.