التداخل بين ديجوكسين وفيلازودون

Concomitant use of VIIBRYD increased digoxin concentrations [see Clinical Pharmacology ( 12.3 )] .

Continue monitoring and reduce digoxin dose as necessary.

Digoxin Digoxin is a narrow therapeutic index drug.

Measure serum digoxin concentrations before initiating concomitant use of VIIBRYD.

…Interactions With VIIBRYD Based on pharmacokinetic studies, no dosage adjustment is required for drugs that are substrates of CYP1A2, CYP2B6, CYP2C9, CYP2C19, CYP2D6, CYP3A4, and/or P-glycoprotein (except narrow therapeutic index drugs, e.g., digoxin), when VIIBRYD is administered concomitantly [see Drug Interactions ( 7.1 ), Clinical Pharmacology ( 12.3 )] .