التداخل بين دينوبروستون وسالسالات

Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion.

In these patients, administration of a nonsteroidal anti-inflammatory drug may cause a dose-dependent reduction in prostaglandin formation and, secondarily, in renal blood flow, which may precipitate overt renal decompensation.

This response has been attributed to inhibition of renal prostaglandin synthesis.

These effects have been attributed to inhibition of renal prostaglandin synthesis by the NSAID.