التداخل بين ديفينهيدرامين وميكليزين

Drug Interactions Diphenhydramine hydrochloride has additive effects with alcohol and other CNS depressants (hypnotics, sedatives, tranquilizers, etc).

• Coadministration of meclizine hydrochloride with other CNS depressants, including alcohol, may result in increased CNS depression ( 7.1 ).

• CYP2D6 inhibitors: As meclizine is metabolized by CYP2D6, there is a potential for drug-drug interactions between meclizine hydrochloride and CYP2D6 inhibitors ( 7.2 ).

CYP2D6 Inhibitors Based on in-vitro evaluation, meclizine is metabolized by CYP2D6.

Therefore, there is a possibility for a drug interaction between meclizine hydrochloride and CYP2D6 inhibitors.