التداخل بين ديفالبروكس (فالبروات) وميثوهيكسيتال

All patients receiving concomitant barbiturate therapy should be closely monitored for neurological toxicity.

Serum barbiturate concentrations should be obtained, if possible, and the barbiturate dosage decreased, if appropriate.

There is evidence for severe CNS depression, with or without significant elevations of barbiturate or valproate serum concentrations.

Primidone, which is metabolized to a barbiturate, may be involved in a similar interaction with valproate.