التداخل بين ديفالبروكس (فالبروات) وبروتريبتيلين

Protriptyline may enhance the response to alcohol and the effects of barbiturates and other CNS depressants.

In contrast, drugs that are inhibitors of cytochrome P450 isozymes, e.g., antidepressants, may be expected to have little effect on valproate clearance because cytochrome P450 microsomal mediated oxidation is a relatively minor secondary metabolic pathway compared to glucuronidation and beta-oxidation.