التداخل بين دولوتيغرافير ونابروكسين وإيزوميبرازول

• Decreased exposure of some antiretroviral drugs (e.g., rilpivirine, atazanavir, and nelfinavir) when used concomitantly with esomeprazole magnesium may reduce antiviral effect and promote the development of drug resistance [see Clinical Pharmacology (12.3) ].

• Increased exposure of other antiretroviral drugs (e.g., saquinavir) when used concomitantly with esomeprazole magnesium may increase toxicity [see Clinical Pharmacology (12.3) ].

Antiretrovirals Clinical Impact : The effect of esomeprazole magnesium on antiretroviral drugs is variable.

• There are other antiretroviral drugs which do not result in clinically relevant interactions with esomeprazole magnesium.

Other antiretrovirals : See prescribing information of specific drugs.